RAF Typhoon fighter aircraft have operated alongside French aircraft in a coordinated attack on an underground arms cache in Syrian territory used by the IS group, according to the UK's MoD.
The facility, pinpointed through surveillance, was assessed as housing weapons and explosive materials, the announcement noted, and was situated in hills just north of the ancient city of Palmyra in Syria's central region.
"Our aircraft used laser-guided Paveway IV weapons to target a several entry passages down to the site... initial indications suggest the target was engaged successfully," officials stated.
There was no indication of any harm to civilians in the operation on Saturday evening and each participating jet made a safe return, the defence officials confirmed.
The British jets were supported by a Voyager aerial refuelling aircraft.
The Islamic State group - alternatively referred to as Daesh - established extremist governance over significant areas in Syria and Iraq before its territorial defeat in 2019.
"This strike demonstrates our UK leadership, and commitment to work closely with our partners, to eliminate any resurgence of the terrorist group and their dangerous and violent ideologies in the area," the British Defence Secretary John Healey remarked.
British military aircraft have carried out overwatch operations over Syria to "deter any attempted comeback" of IS subsequent to its military defeat at the Baghuz confrontation in 2019, the ministry said.
"I want to thank every member of our armed forces participating in this operation for their skill and their bravery," the Defence Secretary added. "Including them were thousands of British personnel deployed over Christmas and New Year. This mission, to remove dangerous terrorists who threaten our way of life, highlights how British military are ready to step up, continuously, ensuring Britain's security domestically and strong abroad."
Last December, the United States armed forces conducted what it described as a "large-scale strike" against IS targets in the country, following an attack resulted in the deaths of two American soldiers and a civilian interpreter in Palmyra.
The United Nations says IS still boasts between 5,000 and 7,000 militants in Syria and Iraq.